San Angelo is located near the geographic center of Texas. The area is known as the Concho Valley, named for the Concho River that runs through the city. San Angelo is one of the largest cities in the United States that is not located directly on an Interstate. It is located about equidistant between two Interstates, I-20 to the north and I-10 to the south. 

The South Gate is located off S Chadbourne St. The North Gate is located off Paint Rock Rd.

From Dallas/Fort Worth:
Take Texas 121 TEXpress/Texas 183 TEXpress, I-820 W and I-20 W to I-20 Frontage W in Cisco. Take exit 330 from I-20 W

1 h 55 min (132 mi)

Follow TX-206 S and US-67 S to San Angelo
2 h 4 min (124 mi)

From Austin:
Get on TX-71 W in Del Valle from Hotel Dr and Spirit of Texas Dr

2 min (0.8 mi)

Follow TX-71 and US-87 N to San Angelo
3 h 19 min (205 mi)

From San Antonio:

From El Paso:
Get on I-10 E from Airway Blvd and Gateway Blvd E

7 min (2.8 mi)

Follow I-10 E to US-385 N/US-67 N in Pecos County. Take exit 273 from I-10 E
3 h 27 min (247 mi)

Follow to TX-306 Loop E in San Angelo
2 h 14 min (145 mi)

From Midland/Odessa:
Take N Lamesa Rd and TX-158 BUS E to TX-158 E

14 min (5.7 mi)

Continue on TX-158 E to San Angelo
1 h 43 min (111 mi)

From San Antonio:
Get on I-410 W from S Terminal Dr and I- 410 Access Rd/NE Interstate 410 Loop

5 min (1.5 mi)

Follow I-10 W to US-377 N/US-83 N/N Main St in Kimble County. Take exit 456 from I-10 W
1 h 36 min (112 mi)

Follow US-83 N and US-87 N to San Angelo
1 h 27 min (93.0 mi)


San Angelo Regional Airport has six flights per day to Dallas-Fort Worth